Our team at Clinical Research & Evidence-Based Unit operates an extensive evidence synthesis programme in collaboration with other academic entities. Main aims of the programme are:
- To formulate critical questions of clinical relevance to patients and healthcare providers
- To systematically appraise and synthesise the available body of evidence for common healthcare interventions and diagnostic tests
- To identify areas of uncertainty in healthcare
- To minimise redundant research
- To develop scientifically sound clinical practice recommendations tailored to every individual patient’s needs
Selected publications of our team include:
Research reporting methods
- Methods for depicting overlap in overviews of systematic reviews: An introduction to static tabular and graphical displays. Journal of Clinical Epidemiology (2020)
- Preferred Reporting Items for Overviews of sytematic reviews including harms checklist: A pilot tool to be used for balanaced reporting of benefits and harms. Journal of Clinical Epidemiology (2017)
Guidelines development
- 2019 Update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care & Diabetologia (2019)
- Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care & Diabetologia (2018)
- Management of hyperglycaemia in type 2 diabetes, 2015: a patient-centred approach: update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care & Diabetologia (2015)
- Management of hyperglycaemia in type 2 diabetes: a patient-centred approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care & Diabetologia (2012)
Systematic reviews and meta-analyses of healthcare interventions
- GLP-1 receptor agonists and SGLT2 inhibitors for older people with type 2 diabetes: A systematic review and meta-analysis. Diabetes Research and Clinical Practice (2021)
- Comparative efficacy and safety of glucose-lowering drugs as adjunctive therapy for adults with type 1 diabetes: A systematic review and network meta-analysis. Diabetes Obesity Metabolism (2021)
- Omega-3 supplementation and cardiovascular disease: formulation-based systematic review and meta-analysis with trial sequential analysis. Heart (2021)
- Comparative Effectiveness of Glucose-Lowering Drugs for Type 2 Diabetes. A Systematic Review and Network Meta-analysis. Annals of Internal Medicine (2020) – Editorial – Letter
- Glucagon-like peptide 1 receptor agonists and sodium glucose co-transporter 2 inhibitors as combination therapy for type 2 diabetes. A systematic review and meta-analysis. Diabetes Obesity Metabolism (2020)
- Effects of mineralocorticoid receptor antagonists in proteinuric kidney disease: a systematic review and meta-analysis of randomized controlled trials. Journal of Hypertension (2019)
- Oral semaglutide for type 2 diabetes: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism (2019)
- Guidelines for Medical Nutrition Therapy in Gestational Diabetes Mellitus: Systematic Review and Critical Appraisal. J Acad Nutr Diet (2019)
- The effect of SGLT-2 inhibitors on albuminuria and proteinuria in diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials. Journal of Hypertension (2019)
- Prevention of orthodontic enamel demineralization: A systematic review with meta-analyses. Orthodontics & Craniofacial Research (2019)
- Carvedilol for prevention of variceal bleeding: a systematic review and meta-analysis. Annals of Gastroenterology (2019)
- Intravenous Immunoglobulin for Patients With Alzheimer’s Disease: A Systematic Review and Meta-Analysis. American Journal of Alzheimer’s Disease & Other Dementias (2019)
- Intravenous Magnesium Sulfate in Acute Stroke. Stroke (2019)
- Systematic review with network meta-analysis: the impact of medical interventions for moderate-to-severe ulcerative colitis on health-related quality of life. Alimentary Pharmacology & Therapeutics (2018)
- Tofacitinib for induction of remission in ulcerative colitis: systematic review and meta-analysis. Annals of Gastroenterology (2018)
- Glucagon-like peptide-1 receptor agonists and microvascular outcomes in type 2 diabetes: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism (2018)
- Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis. Annals of Internal Medicine (2018)
- Semaglutide for type 2 diabetes: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism (2018)
- Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis. The BMJ (2018) – Editorial
- Once-weekly dipeptidyl peptidase-4 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Expert Opinion on Pharmacotherapy (2017)
- Fixed ratio combinations of glucagon like peptide 1 receptor agonists with basal insulin: a systematic review and meta-analyis. Endocrine (2017)
- Association between response rates and survival outcomes in patients with newly diagnosed multiple myeloma. A systematic review and meta-regression analysis. European Journal of Haematology (2017)
- Antigen-based immunotherapies do not prevent progression of recent-onset autoimmune diabetes: a systematic review and meta-analysis. Endocrine (2016)
- A systematic review and meta-analysis of off-loading methods for diabetic foot ulcers. Journal of Vascular Surgery (2016)
- A systematic review and meta-analysis of adjunctive therapies in diabetic foot ulcers. Journal of Vascular Surgery (2016)
- A systematic review and meta-analysis of débridement methods for chronic diabetic foot ulcers. Journal of Vascular Surgery (2016)
- A systematic review and meta-analysis of tests to predict wound healing in diabetic foot. Journal of Vascular Surgery (2016)
- A systematic review and meta-analysis of glycemic control for the prevention of diabetic foot syndrome. Journal of Vascular Surgery (2016)
- Systematic review and meta-analysis of vildagliptin for treatment of type 2 diabetes. Endocrine (2015)
- Efficacy and safety of once-weekly glucagon-like peptide 1 receptor agonists for the management of type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. Diabetes, Obesity and Metabolism (2015)
- Pharmacologic interventions for painful diabetic neuropathy: an umbrella systematic review and comparative effectiveness network meta-analysis. Annals of Internal Medicine (2014) – Editorial & Protocol
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Efficacy and safety of empagliflozin for type 2 diabetes: a systematic review and meta-analysis. Diabetes, Obesity and Metabolism (2014)
- Sodium-glucose cotransporter 2 inhibitors for type 2 diabetes: a systematic review and meta-analysis. Annals of Internal Medicine (2013) – Accompanying research paper
- Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis. The BMJ (2012) – Editorial
Diagnostic test accuracy systematic reviews and meta-analyses
- Performance of Baveno VI and Expanded Baveno VI Criteria for Excluding High-risk Varices in Patients with Chronic Liver Diseases: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology (2019)
- Diagnostic accuracy of fecal immunochemical test in patients at increased risk for colorectal cancer: a meta-analysis. JAMA Internal Medicine (2017) – Editorial
- Accuracy of magnetic resonance imaging in diagnosis of liver iron overload: a systematic review and meta-analysis. Clinical Gastroenterology and Hepatology (2014) – Editorial & CME exam
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A simple plaster for screening for diabetic neuropathy: a diagnostic test accuracy systematic review and meta-analysis. Metabolism, Clinical and Experimental (2014)